Associate Professor of Statistics, Bioengineering and Computer Science

Ph.D. in Biostatistics, Harvard University, 2005

Website

Research Interests

• Statistical development in computational biology
• Statistical computing
• Applications to genomics, evolution and systems biology

Honors and Appointments

• Member, Computational Science & Engineering Program, UIUC
• Member, Biophysics & Computational Biology Program, UIUC
• Affiliate member, Institute for Genomic Biology, UIUC

Selected Publications: Methods

• Zhong S, Tian L, Li C, Storch FK, and Wong WH (2004). Comparative Analysis of Gene Sets in the Gene Ontology Space under the Multiple Hypothesis Testing Framework. Proc IEEE Computational Systems Bioinformatics (CSB) 2004: 425-435.
• Li X, Zhong S, Wong WH (2005). Reliable identification of transcription factor binding sites using phylogenetic verification. PNAS 102: 16945-16950.
• Lin G, He X, Ji H, Shi L, Davis R, Zhong S (2006). Reproducibility Probability Score - incorporating measurement variability across laboratories for gene selection. Nature Biotechnology, 24(12): 6-7.
• Kim C, Kim S, Dorer R, Xie D, Han J, Zhong S (2007). TagSmart: Software for Analysis and Visualization of Yeast Mutant Fitness Data Measured by TAG Microarrays. BMC Bioinformatics. 8:128

Selected Publications: Applications

• Zhong S, Li C and Wong WH (2003). ChipInfo: Software for Extracting Gene Annotation and Gene Ontology Information for Microarray Analysis. Nucleic Acids Research, 31(13): 3487-3490. 2003.
• Zhong S, Storch F, Lipan O, Kao MJ, Weitz C, Wong WH (2004). GoSurfer: a graphical interactive tool for comparative analysis of large gene sets in Gene Ontology space. Applied Bioinformatics 3(4): 1-5. GoSurfer is rated as "the fastest Gene Ontology analysis tool" by Bioinformatics 21(18):3587-3595
• Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW (2005). A Small Molecule Inhibitor of Mps1 Blocks the Spindle Checkpoint Response to a Lack of Tension on Mitotic Chromosome. Current Biology 15(11): 1070-1076. This article is discussed by Research Highlights on Nature Methods 2:566-567. This article is rated as "must read" by Faculty of 1000
• Dannenberg JH, David G, Zhong S, Wong WH, DePinho RA (2005). mSin3A co-repressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes & Development 19: 1581-1595. 2005. This article is rated as "must read" by Faculty of 1000
• The MAQC Consortium. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nature Biotechnology, 24(9): 1151-1161. 2006. This article is discussed by News of the week on Science 313: 1559; Analysis on Cell 127: 657-659; Research Highlights on Nature Methods 3: 772; News on Analytical Chemistry 78: 7358-7360
• Vokes SA, Ji H, McCuine S, Tenzen T, Giles S, Zhong S, Wong WH, McMahon AP (2007). Genomic Characterization of Gli1 Transcriptional Inputs in Mammalian Neural Tube. Development. Accepted